Structure-Based Statistical Mechanical Model

Guarnera, E. & Berezovsky, I. N. Structure-Based Statistical Mechanical Model Accounts for the Causality and Energetics of Allosteric Communication. PLoS Comput Biol 12, e1004678 (2016).

Allosteric mutation

Kurochkin, I. V., Guarnera, E., Wong, J. H., Eisenhaber, F. & Berezovsky, I. N. Toward Allosterically Increased Catalytic Activity of Insulin-Degrading Enzyme against Amyloid Peptides. Biochemistry 56, 228–239 (2017).

Identifying, inducing and tuning targeted allosteric response

Tee, W. V., Guarnera, E. & Berezovsky, I. N. Reversing allosteric communication: from detecting allosteric sites to inducing and tuning targeted allosteric response. PLoS Comput Biol 14, e1006228 (2018).

Web-server for allosteric and mutation analysis

Guarnera, E., Tan, Z. W., Zheng, Z. & Berezovsky, I. N. AlloSigMA: allosteric signaling and mutation analysis server. Bioinformatics 33, 3996–3998 (2017).

Allosteric Modulation and Allosteric Signaling Maps

Guarnera, E. & Berezovsky, I. N. Towards comprehensive allosteric control over protein activity. Submitted (2018). bioRxiv 384198; doi:

Supported web browsers

This database has been tested on the following browsers:

  • Mozilla Firefox Version 52+
  • Google Chrome Version 53+

For optimal browsing experience, we recommend using Firefox Version 52 and higher. Chrome users may experience technical issues when accessing proteins with more than 1800 residues.

Contact information

For technical issues, please contact the webmaster.

Data visualization packages

Protein structures are visualized using the PV package: DOI 10.5281/zenodo.20980

Allosteric Signaling Maps are generated, and may be modified, using Plotly.js: Plotly Technologies Inc. Collaborative data science. Montréal, QC, 2015